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New CARS Nano Diamond Imaging Technology

Recently, British scientists have developed a new microscope technology that can be used in observing the nano diamond in living cells. The technology is of great significance to medical research and clinic treatment.

From: iAbrasive.comDate: 2014-10-18 03:55:28Views: 427

Recently, British scientists have developed a new microscope technology that can be used in observing the nano diamond in living cells. The technology is of great significance to medical research and clinic treatment. Nano diamond cells are low in toxicity, which make them possible to be the media of medical imaging and sensing, as well as the carrier of drug delivery. Currently, a large number of medical facilities require the application of nano diamond fluorophors, such as nitro-vacancy center. The fluorophors can only be used by laser technology, the manufacturing process of which is complicated and the equipment is expensive.

While the Raman scattering technique is helpful in achieving the analysis on non-fluorophors nano diamond. The operators shelled the sample diamond by laser that can contact and react with the vibrating chemical bonds, whose vibration frequency can be calculated by scattered photons. However, the Raman scattering technique is relatively weak that it takes longer time to imaging clearly, which is a malpractice for organisms. Scientists have developed the CARS technology that can shorten imaging time by two infrared laser beams. When the frequency difference between two infrared laser beams equals to the vibration frequency of chemical bonds, all the same chemical bonds start synchronous vibration, thus the signal is strengthened and the imaging time is shorten. The technology is of vital importance to nano diamond medical facilities, especially when a large number of carbon-carbon bonds are produced.

Professor Paola Borri from University of Cardiff and his colleagues conducted an imaging experiment on nano diamond whose semidiameter is 70nm to 150nm with self-made CARS microscope in water. The imaging data observed by the microscope revealed that the smallest size of a single nano diamond is 27nm. In fact, nano diamond used in medical cause is much smaller in sizes, which is often 1nm to 2nm. Despite the fact, Professor Paola Borri is confident in his CARS microscope.

Diamond-imaging-CARS-nano

When observing specific cells, for example, cancer cell, the sizes of nano particles should not be too small, or they may easily be ignored. Paola Borri says, "Now we are able to connect CARS with nano diamond quantity measurement, and observe single diamond particles. The direct measurement of nano diamond's normal position in living cells cannot be achieved by traditional phosphor technology. Currently, the researchers are succeeded in clear imaging of nano diamond in human cells, and all the process does zero harm to living bodies."

Author: Liwei Chu
Copyright: iAbrasive.com--Abrasives & Diamond Tools Market

 

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